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Isoxaben Quickview (CASRN 82558-50-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Isoxaben

File First On-Line: 09/26/1988; Last Significant Revision: 09/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 04/01/1991
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 10/01/1993
Synonyms
  • 82558-50-7
  • Caswell No. 419f
  • Compound 121607
  • EL-107
  • EPA Pesticide Chemical Code 125851
  • Isoxaben
  • n-(3-(1-Ethyl-1-methylpropyl)isoxazol-5-yl)-2,6-dimethoxybenzamide
  • n-(3-(1-Ethyl-methylpropyl)-5-isoxazolyl)-2,6-dimethoxybenzamide
  • n-(3-(1-Ethyl-1-methylpropyl)-5-isoxazolyl)-2,6-dimethoxybenzamide (9ci)
  • Benzamide, n-(3-(1-ethyl-1-methylpropyl)-5-isoxazolyl)-2,6-dimethoxy-
Isoxaben Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Increased BUN; decreased serum AP and AST; decreased food consumption efficiency; increased heart/body weight NOEL : 5 mg/kg-day 100 5 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Based on a statistically significant increased incidence of benign liver tumors in one species.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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