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Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) Quickview (CASRN 121-82-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

File First On-Line: 09/26/1988; Last Significant Revision: 08/01/1990

Category (section)
Last Revised
Oral RfD Assessment On-line 02/01/1993
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 07/01/1993
Under Re-Assessment
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  • more...
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Inflammation of the prostate NOEL : 3 x10-1 mg/kg-day 100 3 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Hepatocellular adenomas and carcinomas in female B6C3F1 mice.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.1 x10-1 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
3.1x10-6 per µg/L
Risk Level
E-4 (1 in 10,000) 3x101 µg/L
E-5 (1 in 100,000) 3 µg/L
E-6 (1 in 1,000,000) 3x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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