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Cumene Quickview (CASRN 98-82-8)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Cumene

File First On-Line: 09/07/1988; Last Significant Revision: 08/01/1997

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 08/01/1997
Inhalation RfC Assessment On-line 08/01/1997
Carcinogenicity Assessment On-line 08/01/1997
Synonyms
  • Cumene
  • Isopropyl benzene
  • 2-Phenylpropane
  • 98-82-8
  • Isopropylbenzol
Cumene Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Increased average kidney weight in female rats NOAEL : 1.10 x102 mg/kg-day 1000 1 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Increased kidney weights in female rats and adrenal weights in male and female rats NOAEL (HEC): 4.35 x102 mg/m3 1000 4x10-1 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
    • Carcinogenic potential cannot be determined
  • Weight-of-Evidence Narrative:
    • Under the proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), it is concluded that the carcinogenic potential of cumene cannot be determined because no adequate data, such as well-conducted long-term animal studies or reliable human epidemiological studies, are available for any assessment.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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