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Methanol Quickview (CASRN 67-56-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Methanol

File First On-Line: 09/07/1988; Last Significant Revision: 09/30/2013

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/30/2013
Inhalation RfC Assessment On-line 09/30/2013
Carcinogenicity Assessment Message 09/30/2013
Synonyms
  • 67-56-1
  • Carbinol
  • Methanol
  • Methyl alcohol
  • Wood alcohol
  • Wood-spirit
  • Methyl hydroxide
  • Monohydroxymethane
  • Pyroxylic spirit
  • Wood naptha
Methanol Source Documents
Revision History
Date Section Description
09/30/2013 I., VI., VIII. RfD assessment updated. RfC added.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Extra cervical ribs BMDL05 (internal): 43.1 mg/L 100 2 mg/kg-day

* The RfD is the oral dose predicted to yield a methanol blood concentration equal to an RfDinternal of 0.43 mg/L, which is derived from the Point of Departure adjusted by the 100-fold uncertainty factor. See discussion of Principal and Supporting Studies (Oral RfD).

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Reduced brain weight in rat pups at 6 weeks of age BMDL1SD (internal): 858 mg-hr/L 100 2x101 mg/m3

* The RfC is the inhalation concentration predicted to yield a methanol blood concentration equal to an RfCinternal of 8.58 mg-hr/L, which is derived from the Point of Departure adjusted by the 100-fold uncertainty factor. See discussion of Principal and Supporting Studies (Inhalation RfC).

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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