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Chloral hydrate Quickview (CASRN 302-17-0)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Chloral hydrate

File First On-Line: 08/22/1988; Last Significant Revision: 09/15/2000

Category (section)
Last Revised
Oral RfD Assessment Yes 09/15/2000
Inhalation RfC Assessment Discussion 09/15/2000
Carcinogenicity Assessment Yes 09/15/2000
  • Chloral monohydrate
  • Trichloroacetaldehyde hydrate
  • Trichloroacetaldehyde monohydrate
  • Chloral hydrate
  • 1,1,1-Trichloro-2,2-dihydroxyethane
Chloral hydrate Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
CNS depression and GI irritation in humans LOAEL : 1.07 x101 mg/kg-day 100 1 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
    • Carcinogenic potential cannot be determined (Oral route)
  • Weight-of-Evidence Narrative:
    • Under the 1986 cancer guidelines (U.S. EPA, 1986), chloral hydrate is assigned to Group C, possible human carcinogen. Under the 1996 proposed guidelines for carcinogen risk assessment (U.S. EPA, 1996), chloral hydrate shows suggestive evidence of human carcinogenicity by the oral route of exposure. There are no carcinogenicity data from humans.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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