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2-Methylphenol Quickview (CASRN 95-48-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 2-Methylphenol

File First On-Line: 09/07/1988; Last Significant Revision: 04/01/1992

Category (section)
Last Revised
Oral RfD Assessment Yes 09/07/1988
Inhalation RfC Assessment Message 04/01/1992
Carcinogenicity Assessment Yes 09/01/1990
  • 95-48-7
  • Phenol, 2-methyl-
  • Cresols (o-,m-,p-)
  • HSDB 1813
  • NSC 23076
  • NSC 36809
  • o-Cresol
  • o-Cresylic acid
  • o-Hydroxytoluene
  • o-Kresol [German]
  • o-Methylphenol
  • more...
2-Methylphenol Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Date were removed from IRIS on or before April 1997. IRIS users were directed to the appropirate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Decreased body weights and neurotoxicity NOAEL : 5.0 x101 mg/kg-day 1000 5 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Based on an increased incidence of skin papillomas in mice in an initiation-promotion study. The three cresol isomers produced positive results in genetic toxicity studies both alone and in combination.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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