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Butyl benzyl phthalate Quickview (CASRN 85-68-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Butyl benzyl phthalate

File First On-Line: 08/22/1988; Last Significant Revision: 09/01/1989

Category (section)
Last Revised
Oral RfD Assessment Yes 09/01/1989
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 08/22/1988
Under Re-Assessment
  • 85-68-7
  • BBP
  • 1,2-Benzenedicarboxylic acid, butyl phenylmethyl ester
  • Benzyl-butylester kyseliny ftalove
  • Benzyl butyl phthalate
  • Benzyl n-butyl phthalate
  • Butyl benzyl phthalate
  • n-Butyl benzyl phthalate
  • Butyl phenylmethyl 1,2-benzenedicarboxylate
  • NCI-C54375
  • Palatinol BB
  • more...
Butyl benzyl phthalate Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Significantly increased liver-to-body weight and liver-to-brain weight ratios NOAEL : 1.59 x102 mg/kg-day 1000 2 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Based on statistically significant increase in mononuclear cell leukemia in female rats; the response in male rats was inconclusive and there was no such response in mice.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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