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Acrylamide Quickview (CASRN 79-06-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Acrylamide

File First On-Line: 09/26/1988; Last Significant Revision: 03/09/2011

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 03/22/2010
Inhalation RfC Assessment On-line 03/22/2010
Carcinogenicity Assessment On-line 03/22/2010
Synonyms
  • 79-06-1
  • Acrylamide
  • Acrylic amide
  • Ethylenecarboxamide
  • Propenamide
  • Acrylic acid amide
  • Propenoic acid amide
  • Vinyl amide
Acrylamide Source Documents
Revision History
Date Section Description
03/09/2011 NA Corrections that were made to Table 3-2 of the Toxicological Review of Acrylamide: 1. Some of the superscripts were missing or wrong. 2. The species "hamster" should be "humans". 3. Citaion "j" Fennell et al 2005 should be Fennell et al 2006 4. All citations for Hartmann et al., 2008, 224480 should be Kopp and Dekant, 2009, 224532
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Degenerative nerve changes HED (BMDL): 0.053 mg/kg-day 30 0.002 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Degenerative nerve changes HEC5 (BMDL): 0.18 mg/m3 30 0.006 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • In accordance with the Guidelines for Carcinogen Risk Assessment U.S. EPA, 2005, acrylamide (AA) is characterized as "likely to be carcinogenic to humans."
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
5 x10-1 per mg/kg-day Multistage model with linear extrapolation from the point of departure (BMDL), summed risk.
Drinking Water Unit Risks
x10

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
1 x10-4 per µg/m3 Multistage model with linear extrapolation from the point of departure (BMDL), summed risk.

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