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Nickel subsulfide Quickview (CASRN 12035-72-2)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Nickel subsulfide

File First On-Line: 09/30/1987; Last Significant Revision: 09/30/1987

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 09/30/1987
  • Heazlewoodite
  • Nickel subsulfide
  • Nickel sulfide
  • alpha-Nickel sulfide (3:2) crystalline
  • Nickel sulphide
  • 12035-72-2
  • Nickel subsulphide
  • Nickel tritadisulphide
Nickel subsulfide Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • A (Human carcinogen)
  • Weight-of-Evidence Narrative:
    • Increased risks of lung and nasal cancer in humans exposed to nickel refinery dust, most of which was believed to have been nickel subsulfide; increased tumor incidences in animals by several routes of administration in several animal species and strains; and positive results in genotoxicity assays form the basis for this classification.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
4.8 x10-4 per µg/m3 Additive and multiplicative

Inhalation Concentrations at Specified Risk Levels

Risk Level
E-4 (1 in 10,000) 2x10-1 µg/m3
E-5 (1 in 100,000) 2x10-2 µg/m3
E-6 (1 in 1,000,000) 2x10-3 µg/m3

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