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Nickel refinery dust Quickview (CASRN NA)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Nickel refinery dust

File First On-Line: 09/30/1987; Last Significant Revision: 01/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 01/01/1991
Synonyms
  • 7440-02-0
  • Nickel refinery dust
  • Nickel dust
  • Nickel particles
Nickel refinery dust Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Adivsories, EPA Regulatory Actions, and Supplementary Data were removed on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • A (Human carcinogen)
  • Weight-of-Evidence Narrative:
    • Human data in which exposure to nickel refinery dust caused lung and nasal tumors in sulfide nickel matte refinery workers in several epidemiologic studies in different countries, and on animal data in which carcinomas were produced in rats by inhalation and injection.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
2.4 x10-4 per µg/m3 Additive and multiplicative

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 4x10-1 µg/m3
E-5 (1 in 100,000) 4x10-2 µg/m3
E-6 (1 in 1,000,000) 4x10-3 µg/m3

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