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Xylenes Quickview (CASRN 1330-20-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Xylenes

File First On-Line: 09/30/1987; Last Significant Revision: 02/21/2003

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/21/2003
Inhalation RfC Assessment On-line 02/21/2003
Carcinogenicity Assessment On-line 02/21/2003
Synonyms
  • 1,2-Dimethylbenzene
  • m-Xylene
  • ortho-Xylene
  • Xylenes
  • 1330-20-7
  • 106-42-3
  • Dimethylbenzene
  • 1,3-Dimethylbenzene
  • 1,4-Dimethylbenzene
  • Mixed xylenes
  • meta-Xylene
  • more...
Xylenes Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Decreased body weight, increased mortality NOAEL : 1.79 x102 mg/kg-day 1000 0.2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Impaired motor coordination (decreased rotarod performance) NOAEL (HEC): 39 mg/m3 300 0.1 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Data are inadequate for an assessment of human carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), data are inadequate for an assessment of the carcinogenic potential of xylenes. Adequate human data on the carcinogenicity of xylenes are not available, and the available animal data are inconclusive as to the ability of xylenes to cause a carcinogenic response. Evaluations of the genotoxic effects of xylenes have consistently given negative results.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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