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2,4,6-Trinitrotoluene (TNT) Quickview (CASRN 118-96-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for 2,4,6-Trinitrotoluene (TNT)

File First On-Line: 09/26/1988; Last Significant Revision: 06/01/1989

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/01/1993
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 07/01/1993
Synonyms
  • 118-96-7
  • Entsufon
  • NCI-C56155
  • TNT
  • alpha-TNT
  • TNT-tolite
  • Tolit
  • 2,4,6-Trinitrotolueen
  • 2,4,6-Trinitrotoluene
  • Trinitrotoluene, 2,4,6-
  • s-Trinitrotoluene
  • more...
2,4,6-Trinitrotoluene (TNT) Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Liver effects LOAEL : 5 x10-1 mg/kg-day 1000 5 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Evidence of human carcinogenicity is inadequate. Urinary bladder papilloma and carcinoma were observed in female Fischer 344 rats. Mutagenic activity was observed in Salmonella with and without metabolic activation.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
3.0 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
9.0x10-7 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 1x102 µg/L
E-5 (1 in 100,000) 1x101 µg/L
E-6 (1 in 1,000,000) 1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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