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Trifluralin Quickview (CASRN 1582-09-8)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Trifluralin

File First On-Line: 09/30/1987; Last Significant Revision: 07/01/1989

Category (section)
Last Revised
Oral RfD Assessment Yes 07/01/1989
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 08/22/1988
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Trifluralin Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Increased liver weights; increase in methemoglobin NOEL : 7.5 x10-1 mg/kg-day 100 7.5 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Classification is based on the induction of urinary tract tumors (renal pelvis carcinomas and urinary bladder papillomas) and thyroid tumors (adenomas/carcinomas combined) in one animal species (F344 rats) in one study. Trifluralin is structurally similar to ethalfluralin, a carcinogen in the rat.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
7.7 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
2.2x10-7 per µg/L
Risk Level
E-4 (1 in 10,000) 5x102 µg/L
E-5 (1 in 100,000) 5x101 µg/L
E-6 (1 in 1,000,000) 5 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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