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1,1,1,2-Tetrachloroethane Quickview (CASRN 630-20-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for 1,1,1,2-Tetrachloroethane

File First On-Line: 09/30/1987; Last Significant Revision: 03/01/1989

Category (section)
Last Revised
Oral RfD Assessment Yes 09/30/1987
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 03/01/1989
  • 630-20-6
  • Ethane, 1,1,1,2-tetrachloro-
  • Ethane, 1,1,1,2-tetrachloro- (8ci)(9ci)
  • HSDB 4148
  • NCI-C52459
  • RCRA Waste Number U208
  • 1,1,1,2-Tetrachloroethane
  • Tetrachloroethane, 1,1,1,2-
  • Tetrachloroethane
1,1,1,2-Tetrachloroethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Mineralization of the kidneys in males, hepatic clear cell change in females LOAEL : 8.93 x101 mg/kg-day 3000 3 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Increased incidence of combined hepatocellular adenomas and carcinomas in female mice; inadequate evidence from human studies.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
2.6 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
7.4x10-7 per µg/L
Risk Level
E-4 (1 in 10,000) 1x102 µg/L
E-5 (1 in 100,000) 1x101 µg/L
E-6 (1 in 1,000,000) 1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
7.4 x10-6 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
E-4 (1 in 10,000) 1x101 µg/m3
E-5 (1 in 100,000) 1 µg/m3
E-6 (1 in 1,000,000) 1x10-1 µg/m3

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