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beta-Hexachlorocyclohexane (beta-HCH) Quickview (CASRN 319-85-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for beta-Hexachlorocyclohexane (beta-HCH)

File First On-Line: 09/30/1987; Last Significant Revision: 01/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 07/01/1993
Synonyms
  • beta-Isomer
  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-isomer
  • ENT 9,233
  • 1-alpha,2-beta,3-alpha,4-beta,5-alpha,6-beta-Hexachlorocyclohexane
  • 319-85-7
  • beta-BHC
  • Cyclohexane, 1,2,3,4,5,6-hexachloro-, beta-
  • Cyclohexane, beta-1,2,3,4,5,6-hexachloro-
  • beta-HCH
  • beta-Hexachlorobenzene
  • Hexachlorocyclohexane, beta-
  • more...
beta-Hexachlorocyclohexane (beta-HCH) Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Increases in benign liver tumors in CF1 mice fed beta-HCH
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.8 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
5.3x10-5 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 2 µg/L
E-5 (1 in 100,000) 2x10-1 µg/L
E-6 (1 in 1,000,000) 2x10-2 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
5.3 x10-4 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 2x10-1 µg/m3
E-5 (1 in 100,000) 2x10-2 µg/m3
E-6 (1 in 1,000,000) 2x10-3 µg/m3

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