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Folpet Quickview (CASRN 133-07-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Folpet

File First On-Line: 09/30/1987; Last Significant Revision: 08/22/1988

Category (section)
Last Revised
Oral RfD Assessment Yes 09/30/1987
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 08/22/1988
  • 133-07-3
  • Folpan
  • Folpet
  • Ftalan
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  • n-(Trichlor-methylthio)-phthalamid
  • n-(Trichlormethylthio)phthalimide
  • n-(Trichloromethylmercpato)phthalimide
  • n-(Trichloromethylthio)phthalimide
  • Orthophaltan
  • Phaltan
  • more...
Folpet Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Decreased body weight gain, altered serum chemistry parameters (decreased serum cholesterol, total protein, and serum albumin and globulin levels) NOEL : 1.0 x101 mg/kg-day 100 1 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Folpet has induced carcinoma and adenoma of the duodenum (an unusual site) in both sexes of both CD-1 and B6C3F1 mice. Folpet is also mutagenic in several in vitro assays and is a structural analogue of captan, which has been shown to induce carcinoma in the duodenum of two mouse strains.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
3.5 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.0x10-7 per µg/L
Risk Level
E-4 (1 in 10,000) 1x103 µg/L
E-5 (1 in 100,000) 1x102 µg/L
E-6 (1 in 1,000,000) 1x101 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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