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Dieldrin Quickview (CASRN 60-57-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Dieldrin

File First On-Line: 09/07/1988; Last Significant Revision: 01/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/01/1990
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 07/01/1993
Synonyms
  • 60-57-1
  • Alvit
  • Compound 497
  • Dieldrex
  • Dieldrin
  • Dieldrine
  • Dieldrite
  • 1,4:5,8-Dimethanonaphthalene, 1,2,3,4,10,10-hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro, endo,exo-
  • ENT 16,225
  • Heod
  • Hexachloroepoxyoctahydro-endo,exo-dimethanonaphthalene
  • more...
Dieldrin Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Liver lesions NOAEL : 5 x10-3 mg/kg-day 100 5 x10-5 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Dieldrin is carcinogenic in seven strains of mice when administered orally. Dieldrin is structurally related to compounds (aldrin, chlordane, heptachlor, heptachlor epoxide, and chlorendic acid) which produce tumors in rodents.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.6 x101 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
4.6x10-4 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 2x10-1 µg/L
E-5 (1 in 100,000) 2x10-2 µg/L
E-6 (1 in 1,000,000) 2x10-3 µg/L
  • Dose-Response Data (Carcinogenicity, Oral Exposure)
    • Tumor Type: Liver carcinoma
    • Test Species: Mouse
    • Route: Oral, Diet
    • Reference: Davis (1965), reevaluated by Reuber, 1974 (cited in Epstein, 1975a); Walker et al., 1972; Thorpe and Walker, 1973; NCI, 1978a,b; Tennekes et al., 1981; Meierhenry et al., 1983

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
4.6 x10-3 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 2x10-2 µg/m3
E-5 (1 in 100,000) 2x10-3 µg/m3
E-6 (1 in 1,000,000) 2x10-4 µg/m3
  • Dose-Response Data (Carcinogenicity, Inhalation Exposure)
    • Tumor Type: Liver carcinoma
    • Test Species: Mouse
    • Route: Oral, Diet
    • Reference: Davis (1965), reevaluated by Reuber, 1974 (cited in Epstein, 1975a); Walker et al., 1972; Thorpe and Walker, 1973; NCI, 1978a,b; Tennekes et al., 1981; Meierhenry et al., 1983

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