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1,3-Dichloropropene Quickview (CASRN 542-75-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for 1,3-Dichloropropene

File First On-Line: 09/30/1987; Last Significant Revision: 05/25/2000

Category (section)
Status
Last Revised
Oral RfD Assessment Yes 05/25/2000
Inhalation RfC Assessment Yes 05/25/2000
Carcinogenicity Assessment Yes 05/25/2000
Synonyms
  • 542-75-6
  • 3-Chloroallyl chloride
  • alpha-Chloroallyl chloride
  • gamma-Chloroallyl chloride
  • 3-Chloropropenyl chloride
  • DCP
  • Dichloropropene
  • 1,3-Dichloropropene-1
  • 1,3-Dichloropropene
  • 1,3-Dichloro-2-propene
  • Dichloropropene, 1,3-
  • more...
1,3-Dichloropropene Source Documents
Revision History
Date Section Description
05/25/2000 II.A. Added oral cancer potency
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Chronic irritation BMDL10 : 3.4 mg/kg-day 100 3 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Hypertrophy/ hyperplasia of the nasal respiratory epithelium BMCL10 (HEC): 7.2 x10-1 mg/m3 30 2x10-2 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
    • Known/likely human carcinogen
  • Weight-of-Evidence Narrative:
    • Although the available human data are inadequate, 1,3-dichloropropene is characterized as "likely" to be a human carcinogen in accordance with the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996).
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1 x10-1 per mg/kg-day Linearized multistage model, extra risk
Drinking Water Unit Risks
3x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 4x101 µg/L
E-5 (1 in 100,000) 4 µg/L
E-6 (1 in 1,000,000) 4x10-1 µg/L
  • Dose-Response Data (Carcinogenicity, Oral Exposure)
    • Tumor Type: Urinary bladder carcinoma
    • Test Species: female mouse
    • Route: Oral, gavage
    • Reference: NTP, 1985
    • Tumor Type: Hepatocellular adenoma/carcinoma
    • Test Species: male rat
    • Route: Oral, gavage
    • Reference: NTP, 1985
    • Tumor Type: Hepatocellular adenoma/carcinoma
    • Test Species: male rat
    • Route: Oral, dietary
    • Reference: Stott et al., 1995

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
4 x10-6 per µg/m3 Linearized multistage model, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 2x101 µg/m3
E-5 (1 in 100,000) 2 µg/m3
E-6 (1 in 1,000,000) 2x10-1 µg/m3

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