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Dibromochloromethane Quickview (CASRN 124-48-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Dibromochloromethane

File First On-Line: 09/30/1987; Last Significant Revision: 01/01/1992

Category (section)
Last Revised
Oral RfD Assessment Yes 09/30/1987
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 01/01/1992
  • 124-48-1
  • Chlorodibromomethane
  • Dibromomonochloromethane
  • Methane, dibromochloro-
  • Monochlorodibromomethane
  • Dibromochloromethane
Dibromochloromethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Hepatic lesions NOEL : 2.14 x101 mg/kg-day 1000 2 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Based on inadequate human data and limited evidence of carcinogenicity in animals; namely, positive carcinogenic evidence in B6C3Fl mice (males and females), together with positive mutagenicity data, and structural similarity to other trihalomethanes, which are known animal carcinogens.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
8.4 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
2.4x10-6 per µg/L
Risk Level
E-4 (1 in 10,000) 4x101 µg/L
E-5 (1 in 100,000) 4 µg/L
E-6 (1 in 1,000,000) 4x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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