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Dibromochloromethane Quickview (CASRN 124-48-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Dibromochloromethane

File First On-Line: 09/30/1987; Last Significant Revision: 01/01/1992

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 03/01/1991
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 01/01/1992
Synonyms
  • 124-48-1
  • Chlorodibromomethane
  • Dibromomonochloromethane
  • Methane, dibromochloro-
  • Monochlorodibromomethane
  • Dibromochloromethane
Dibromochloromethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Hepatic lesions NOEL : 2.14 x101 mg/kg-day 1000 2 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Based on inadequate human data and limited evidence of carcinogenicity in animals; namely, positive carcinogenic evidence in B6C3Fl mice (males and females), together with positive mutagenicity data, and structural similarity to other trihalomethanes, which are known animal carcinogens.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
8.4 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
2.4x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 4x101 µg/L
E-5 (1 in 100,000) 4 µg/L
E-6 (1 in 1,000,000) 4x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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