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Bromodichloromethane Quickview (CASRN 75-27-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Bromodichloromethane

File First On-Line: 09/30/1987; Last Significant Revision: 02/01/1993

Category (section)
Last Revised
Oral RfD Assessment Yes 09/30/1987
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 02/01/1993
  • 75-27-4
  • Bromodichloromethane
  • Dichlorobromomethane
  • Dichloromonobromomethane
  • Methane, bromodichloro-
  • Monobromodichloromethane
Bromodichloromethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Renal cytomegaly LOAEL : 1.79 x101 mg/kg-day 1000 2 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Based on inadequate human data and sufficient evidence of carcinogenicity in two animal species (mice and rats) as shown by increased incidence of kidney tumors and tumors of the large intestine in male and female rats, kidney tumors in male mice, and liver tumors in female mice.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
6.2 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.8x10-6 per µg/L
Risk Level
E-4 (1 in 10,000) 6x101 µg/L
E-5 (1 in 100,000) 6 µg/L
E-6 (1 in 1,000,000) 6x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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