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Acetonitrile Quickview (CASRN 75-05-8)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Acetonitrile

File First On-Line: 09/30/1987; Last Significant Revision: 03/03/1999

Category (section)
Last Revised
Oral RfD Assessment Withdrawn; discussion 03/03/1999
Inhalation RfC Assessment Yes 03/03/1999
Carcinogenicity Assessment Yes 03/03/1999
  • 75-05-8
  • Acetonitril
  • Acetonitrile
  • Cyanomethane
  • Cyanure de methyl
  • Ethanenitrile
  • Ethyl nitrile
  • Methanecarbonitrile
  • Methane, cyano-
  • Methyl cyanide
  • NA 1648
  • more...
Acetonitrile Source Documents
Revision History
Date Section Description
03/03/1999 I., II., VI. RfD withdrawn, discussion added; new RfC and cancer assessment
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
Mortality NOAEL (HEC): 6.0 x101 mg/m3 100 6x10-2 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
    • Carcinogenic potential cannot be determined
  • Weight-of-Evidence Narrative:
    • Under the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), the carcinogenic potential of ACN following inhalation, oral, or dermal exposure is best characterized as "cannot be determined because the existing evidence is composed of conflicting data (e.g., some evidence is suggestive of carcinogenic effects, but other equally pertinent evidence does not confirm any concern)."
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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