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1,2,3-Trichloropropane Quickview (CASRN 96-18-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for 1,2,3-Trichloropropane

File First On-Line: 03/31/1987; Last Significant Revision: 09/30/2009

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/30/2009
Inhalation RfC Assessment On-line 09/30/2009
Carcinogenicity Assessment On-line 09/30/2009
Synonyms
  • Allyl trichloride
  • Glyceryl trichlorohydrin
  • NCI-C60220
  • Propane, 1,2,3-trichloro-
  • Trichlorohydrin
  • 1,2,3-Trichloropropane
  • 96-18-4
  • Glycerol trichlorohydrin
  • Trichloropropane, 1,2,3-
1,2,3-Trichloropropane Source Documents
Revision History
Date Section Description
09/30/2009 I.A., I.B., II. Revised RfD, added RfC and carcinogenicity assessments.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Increased absolute liver weight in male rats BMDL (ADJ): 1.1 mg/kg-day 300 0.004 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
peribronchial lymphoid hyperplasia in male rats BMCL (HEC): 0.90 mg/m3 3000 0.0003 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogenic Risk Assessment (U.S. EPA, 2005a), 1,2,3-trichloropropane is "likely to be carcinogenic to humans", based on a statistically significant and dose-related increase in the formation of multiple tumors in both sexes of two species from an NTP (1993) chronic oral bioassay.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
30 per mg/kg-day Multistage-Weibull model with linear extrapolation from the point of departure (BMDL10).
Drinking Water Unit Risks
  • Dose-Response Data (Carcinogenicity, Oral Exposure)
    • Tumor Type: alimentary system squamous cell neoplasms, liver hepatocellular adenomas or carcinomas, Harderian gland adenomas, uterine/cervix adenomas or carcinomas
    • Test Species: B6C3F1 mice (female)
    • Route: Oral, Oral gavage
    • Reference: NTP (1993)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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