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1,1,2-Trichloroethane Quickview (CASRN 79-00-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 1,1,2-Trichloroethane

File First On-Line: 03/31/1987; Last Significant Revision: 01/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/01/1995
Inhalation RfC Assessment No data 12/01/1992
Carcinogenicity Assessment On-line 02/01/1994
Synonyms
  • 79-00-5
  • Ethane trichloride
  • Ethane, 1,1,2-trichloro-
  • NCI-C04579
  • RCRA Waste Number U227
  • RCRA Waste Number U359
  • Beta-t
  • 1,1,2-Trichlorethane
  • 1,1,2-Trichloroethane
  • 1,2,2-Trichloroethane
  • Trichloroethane, 1,1,2-
  • more...
1,1,2-Trichloroethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Clinical serum chemistry NOAEL : 3.9 mg/kg-day 1000 4 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Hepatocellular carcinomas and pheochromocytomas in one strain of mice forms the basis for this classification. Carcinogenicity was not shown in rats. 1,1,2-Trichloroethane is structurally related to 1,2-dichloroethane, a probable human carcinogen.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
5.7 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.6x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 6x101 µg/L
E-5 (1 in 100,000) 6 µg/L
E-6 (1 in 1,000,000) 6x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
1.6 x10-5 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 6 µg/m3
E-5 (1 in 100,000) 6x10-1 µg/m3
E-6 (1 in 1,000,000) 6x10-2 µg/m3

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