Jump to main content.

1,1,2-Trichloroethane Quickview (CASRN 79-00-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for 1,1,2-Trichloroethane

File First On-Line: 03/31/1987; Last Significant Revision: 09/26/1988

Category (section)
Last Revised
Oral RfD Assessment Yes 09/26/1988
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 03/31/1987
  • 79-00-5
  • Ethane trichloride
  • Ethane, 1,1,2-trichloro-
  • NCI-C04579
  • RCRA Waste Number U227
  • RCRA Waste Number U359
  • Beta-t
  • 1,1,2-Trichlorethane
  • 1,1,2-Trichloroethane
  • 1,2,2-Trichloroethane
  • Trichloroethane, 1,1,2-
  • more...
1,1,2-Trichloroethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Clinical serum chemistry (effects on erythrocytes and depressed humoral immune status) NOAEL : 3.9 mg/kg-day 1000 4 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

Top of page

Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

Top of page

Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Hepatocellular carcinomas and pheochromocytomas in one strain of mice forms the basis for this classification. Carcinogenicity was not shown in rats. 1,1,2-Trichloroethane is structurally related to 1,2-dichloroethane, a probable human carcinogen.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
5.7 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.6x10-6 per µg/L
Risk Level
E-4 (1 in 10,000) 6x101 µg/L
E-5 (1 in 100,000) 6 µg/L
E-6 (1 in 1,000,000) 6x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
1.6 x10-5 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
E-4 (1 in 10,000) 6 µg/m3
E-5 (1 in 100,000) 6x10-1 µg/m3
E-6 (1 in 1,000,000) 6x10-2 µg/m3

Top of page

Recent Additions | Advanced Search | IRIS Home | Environmental Assessment | Research

Local Navigation

Jump to main content.