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1,1,1-Trichloroethane Quickview (CASRN 71-55-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 1,1,1-Trichloroethane

File First On-Line: 03/31/1987; Last Significant Revision: 09/28/2007

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/28/2007
Inhalation RfC Assessment On-line 09/28/2007
Carcinogenicity Assessment On-line 09/28/2007
Synonyms
  • Aerothene MM
  • 71-55-6
  • Aerothene tt
  • Chloroetene
  • Chloroethene
  • Chloroethene nu
  • Chloroform, methyl-
  • Chlorothane nu
  • Chlorothene
  • Chlorothene nu
  • Chlorothene vg
  • more...
1,1,1-Trichloroethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Reduced body weight BMDL10 : 2155 mg/kg-day 1000 2 mg/kg-day
(Chronic)

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Liver histopathologic changes NOEL (HEC): 1553 mg/m3 100 5 mg/m3
(Chronic)

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Inadequate information to assess carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for 1,1,1-trichloroethane provides "inadequate information to assess carcinogenic potential."
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

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