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N-Nitroso-N-methylethylamine Quickview (CASRN 10595-95-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for N-Nitroso-N-methylethylamine

File First On-Line: 03/31/1987; Last Significant Revision: 03/01/1988

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 07/01/1993
Synonyms
  • 10595-95-6
  • Ethanamine, n-methyl-n-nitroso-
  • Ethylamine, n-methyl-n-nitroso-
  • Ethylmethylnitrosamine
  • Methylethylnitrosamine
  • Methylethylnitrosoamine
  • Nitrosomethylethylamine
  • Nitroso-n-methylethylamine, n-
  • n-Methyl-n-nitrosoethanamine
  • n-Methyl-n-nitrosoethylamine
  • n-Nitrosoethylmethylamine
  • more...
N-Nitroso-N-methylethylamine Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Increased incidence of tumors of the liver and other sites in two rat strains
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
2.2 x101 per mg/kg-day One-hit
Drinking Water Unit Risks
6.3x10-4 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 2x10-1 µg/L
E-5 (1 in 100,000) 2x10-2 µg/L
E-6 (1 in 1,000,000) 2x10-3 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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