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N-Nitrosodiphenylamine Quickview (CASRN 86-30-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for N-Nitrosodiphenylamine

File First On-Line: 03/31/1987; Last Significant Revision: 03/31/1987

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 07/01/1993
Synonyms
  • 86-30-6
  • Benzenamine, n-nitroso-n-phenyl-
  • Curetard a
  • Delac j
  • Diphenylamine, n-nitroso-
  • Diphenylnitrosamin
  • Diphenylnitrosamine
  • Diphenyl n-nitrosoamine
  • Naugard tjb
  • NCI-C02880
  • Ndpa
  • more...
N-Nitrosodiphenylamine Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Increased incidence of bladder tumors in male and female rats and reticulum cell sarcomas in mice, and structural relationship to carcinogenic nitrosamines
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
4.9 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.4x10-7 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 7x102 µg/L
E-5 (1 in 100,000) 7x101 µg/L
E-6 (1 in 1,000,000) 7 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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