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Hexachloroethane Quickview (CASRN 67-72-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Hexachloroethane

File First On-Line: 03/31/1987; Last Significant Revision: 09/23/2011

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/23/2011
Inhalation RfC Assessment On-line 09/23/2011
Carcinogenicity Assessment On-line 09/23/2011
Synonyms
  • 67-72-1
  • Avlothane
  • Carbon hexachloride
  • Distokal
  • Distopan
  • Distopin
  • Egitol
  • Ethane hexachloride
  • Ethylene hexachloride
  • Falkitol
  • Fasciolin
  • more...
Hexachloroethane Source Documents
Revision History
Date Section Description
09/23/2011 I, II, VI, VIII RfD and cancer assessments updated. RfC added.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Atrophy and degeneration of renal tubules BMDL10 : 0.728 mg/kg-day 1000 7 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Neurotoxicity (tremors and ruffled pelt) NOAEL (HEC): 83 mg/m3 3000 3x10-2 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under the U.S. EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), HCE is "likely to be carcinogenic to humans" based on evidence of multiple tumor types in both sexes of rats and mice (NTP, 1989 NCI, 1978).
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
4 x10-2 per mg/kg-day The multistage model with linear extrapolation from the point of departure (LED10).
Drinking Water Unit Risks
1x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 90 µg/L
E-5 (1 in 100,000) 9 µg/L
E-6 (1 in 1,000,000) 0.9 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

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