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Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD Quickview (CASRN 57653-85-7, 19408-74-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD

File First On-Line: 03/31/1987; Last Significant Revision: 01/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 03/01/1991
Synonyms
  • 19408-74-3
  • 57653-85-7
  • Dibenzo-p-dioxin, 1,2,3,6,7,8-hexachloro-
  • Dibenzo-p-dioxin, 1,2,3,7,8,9-hexachloro-
  • 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin
  • 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin
  • Hexachlorodibenzo-p-dioxin, mixture
  • Hexachlorodibenzo-p-dioxin
  • HXCDD
  • Hexachlorodibenzo-p-dioxin, mixture (HxCDD)
Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Hepatic tumors in mice and rats by gavage
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
6.2 x103 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1.8x10-1 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 6x10-4 µg/L
E-5 (1 in 100,000) 6x10-5 µg/L
E-6 (1 in 1,000,000) 6x10-6 µg/L
  • Dose-Response Data (Carcinogenicity, Oral Exposure)
    • Tumor Type: Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas)
    • Test Species: Mouse/B6C3F1, male; rat/ Osborne-Mendel, female
    • Route: Oral, Gavage
    • Reference: NTP, 1980a

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
1.3 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 8x10-5 µg/m3
E-5 (1 in 100,000) 8x10-6 µg/m3
E-6 (1 in 1,000,000) 8x10-7 µg/m3

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