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technical Hexachlorocyclohexane (t-HCH) Quickview (CASRN 608-73-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for technical Hexachlorocyclohexane (t-HCH)

File First On-Line: 03/31/1987; Last Significant Revision: 01/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 07/01/1993
Synonyms
  • 319-86-8 (delta-hch)
  • Mixture of 1,2,3,4,5,6-hexachlorocyclohexane isomers
  • 319-84-6 (alpha-HCH)
  • 58-89-9 [gamma-HCH (lindane)]
  • 608-73-1
  • 6108-10-7 (epsilon-HCH)
  • 6108-12-9 (eta-HCH)
  • 6108-13-0 (theta-HCH)
  • Hexachlorocyclohexane, technical
  • Hexachlorocyclohexane (t-HCH)
  • T-HCH
  • more...
technical Hexachlorocyclohexane (t-HCH) Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Assays in four strains of mice have yielded positive carcinogenicity results for t-HCH administered in the diet.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.8 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
5.1x10-5 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 2 µg/L
E-5 (1 in 100,000) 2x10-1 µg/L
E-6 (1 in 1,000,000) 2x10-2 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
5.1 x10-4 per µg/m3 Linearized multistage procedure

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 2x10-1 µg/m3
E-5 (1 in 100,000) 2x10-2 µg/m3
E-6 (1 in 1,000,000) 2x10-3 µg/m3

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