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Dichlorvos Quickview (CASRN 62-73-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Dichlorvos

File First On-Line: 03/31/1987; Last Significant Revision: 06/01/1994

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 11/01/1993
Inhalation RfC Assessment On-line 06/01/1994
Carcinogenicity Assessment On-line 12/01/1994
Synonyms
  • Verdican
  • Verdipor
  • Vinyl alcohol, 2,2-dichloro-, dimethyl phosphate
  • Brevinyl
  • UDVF
  • Vaponite
  • Vinylophos
  • Celcusan
  • Atgard
  • Bay-19149
  • Canogard
  • more...
Dichlorvos Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Plasma and RBC ChE inhibition in males and females; brain ChE inhibition in males NOAEL : 5 x10-2 mg/kg-day 100 5 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Decreased brain cholinesterase activity NOAEL (HEC): 5 x10-2 mg/m3 100 5x10-4 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Significant increases in forestomach tumors in female and male B6C3F1 mice and leukemias and pancreatic acinar adenomas in Fischer 344 rats. Supporting evidence included observation of tumors at other sites in the rat and observation of mutagenicity for both dichlorvos and a major metabolite dichloroacetaldehyde. A structurally related material, dichloropropene, also induces forestomach tumors in rodents.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
2.9 x10-1 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
8.3x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 1x101 µg/L
E-5 (1 in 100,000) 1 µg/L
E-6 (1 in 1,000,000) 1x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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