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1,2-Dichloroethane Quickview (CASRN 107-06-2)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 1,2-Dichloroethane

File First On-Line: 03/31/1987; Last Significant Revision: 03/31/1987

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 03/31/1987
  • 107-06-2
  • Ethane, 1,2-dichloro-
  • Ethylene dichloride
  • 1,2-Dichloroethane
  • Dichloroethane, 1,2-
  • Aethylenchlorid [German]
  • AI3-01656
  • alpha,beta-Dichloroethane
  • Bichlorure d'ethylene [French]
  • Borer Sol
  • Brocide
  • more...
1,2-Dichloroethane Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Based on the induction of several tumor types in rats and mice treated by gavage and lung papillomas in mice after topical application
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
9.1 x10-2 per mg/kg-day Linearized multistage procedure with time-to-death analysis, extra risk
Drinking Water Unit Risks
2.6x10-6 per µg/L
Risk Level
E-4 (1 in 10,000) 4x101 µg/L
E-5 (1 in 100,000) 4 µg/L
E-6 (1 in 1,000,000) 4x10-1 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
2.6 x10-5 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
E-4 (1 in 10,000) 4 µg/m3
E-5 (1 in 100,000) 4x10-1 µg/m3
E-6 (1 in 1,000,000) 4x10-2 µg/m3

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