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p,p'-Dichlorodiphenyltrichloroethane (DDT) Quickview (CASRN 50-29-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for p,p'-Dichlorodiphenyltrichloroethane (DDT)

File First On-Line: 03/31/1987; Last Significant Revision: 01/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/01/1996
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 05/01/1991
Synonyms
  • 50-29-3
  • Agritan
  • Anofex
  • Arkotine
  • Azotox
  • Benzene, 1,1'-(2,2,2-trichloroethylidene)bis(4-chloro-)
  • alpha,alpha-Bis(p-chlorophenyl)-beta,beta,beta-trichlorethane
  • 1,1-Bis-(p-chlorophenyl)-2,2,2-trichloroethane
  • 2,2-Bis(p-chlorophenyl)-1,1,1-trichloroethane
  • Bosan Supra
  • Bovidermol
  • more...
p,p'-Dichlorodiphenyltrichloroethane (DDT) Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Office.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Liver lesions NOEL : 5 x10-2 mg/kg-day 100 5 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Observation of tumors (generally of the liver) in seven studies in various mouse strains and three studies in rats. DDT is structurally similar to other probable carcinogens, such as DDD and DDE.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
3.4 x10-1 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
9.7x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 1x101 µg/L
E-5 (1 in 100,000) 1 µg/L
E-6 (1 in 1,000,000) 1x10-1 µg/L
  • Dose-Response Data (Carcinogenicity, Oral Exposure)
    • Tumor Type: Liver tumors, benign and malignant
    • Test Species: Mouse/ CF-1; Mouse/ BALB/C; Rat/ MRC Porton; Rat/ Wistar
    • Route: Oral, Diet
    • Reference: Turusov et al., 1973; Terracini et al., 1973; Thorpe and Walker, 1973; Tomatis and Turusov, 1975; Cabral et al., 1982; Rossi et al., 1977

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
9.7 x10-5 per µg/m3 Linear multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 1 µg/m3
E-5 (1 in 100,000) 1x10-1 µg/m3
E-6 (1 in 1,000,000) 1x10-2 µg/m3
  • Dose-Response Data (Carcinogenicity, Inhalation Exposure)
    • Tumor Type: Liver tumors, benign and malignant
    • Test Species: Mouse/ CF-1; Mouse/ BALB/C; Rat/ MRC Porton; Rat/ Wistar
    • Route: Oral, Diet
    • Reference: Turusov et al., 1973; Terracini et al., 1973; Thorpe and Walker, 1973; Tomatis and Turusov, 1975; Cabral et al., 1982; Rossi et al., 1977

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