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Chlordane (Technical) Quickview (CASRN 12789-03-6)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Chlordane (Technical)

File First On-Line: 03/31/1987; Last Significant Revision: 02/07/1998

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/07/1998
Inhalation RfC Assessment On-line 02/07/1998
Carcinogenicity Assessment On-line 02/07/1998
Synonyms
  • 57-74-9
  • Chlordane
  • Chlor Kil
  • Corodan
  • ENT 9, 932
  • Kypchlor
  • M 140
  • 4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-
  • NCI-C00099
  • Niran
  • Octachlorodihydrodicyclopentadiene
  • more...
Chlordane (Technical) Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Hepatic necrosis NOAEL : 1.5 x10-1 mg/kg-day 300 5 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Hepatic effects NOAEL (HEC): 6.5 x10-1 mg/m3 1000 7x10-4 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
    • Known/likely human carcinogen
  • Weight-of-Evidence Narrative:
    • Under the 1996 Proposed Guidelines, chlordane would be characterized as a likely carcinogen by all routes of exposure.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
3.5 x10-1 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
1x10-5 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 1x101 µg/L
E-5 (1 in 100,000) 1 µg/L
E-6 (1 in 1,000,000) 1x10-1 µg/L
  • Dose-Response Data (Carcinogenicity, Oral Exposure)
    • Tumor Type: Hepatocellular carcinoma
    • Test Species: Mouse/ CD-1 (IRDC); mouse/ B6C3F1(NCI); mouse/ ICR (Khasawinah and Grutsch)
    • Route: Oral, Diet
    • Reference: IRDC, 1973; NCI, 1977; Khasawinah and Grutsch, 1989b

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
1 x10-4 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 1 µg/m3
E-5 (1 in 100,000) 1x10-1 µg/m3
E-6 (1 in 1,000,000) 1x10-2 µg/m3

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