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Cadmium Quickview (CASRN 7440-43-9)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Cadmium

File First On-Line: 03/31/1987; Last Significant Revision: 01/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/01/1994
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 06/01/1992
Under Re-Assessment
Synonyms
  • Cadmium
  • 7440-43-9
  • Kadmium
  • C.I. 77180
Cadmium Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Significant proteinuria NOAEL : 1 x10-2 mg/kg-day 10 1 x10-3 mg/kg-day
(food)
NOAEL : 5 x10-3 mg/kg-day 10 5 x10-4 mg/kg-day
(water)

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B1 (Probable human carcinogen - based on limited evidence of carcinogenicity in humans)
  • Weight-of-Evidence Narrative:
    • Limited evidence from occupational epidemiologic studies of cadmium is consistent across investigators and study populations. There is sufficient evidence of carcinogenicity in rats and mice by inhalation and intramuscular and subcutaneous injection. Seven studies in rats and mice wherein cadmium salts (acetate, sulfate, chloride) were administered orally have shown no evidence of carcinogenic response.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
1.8 x10-3 per µg/m3 Two stage; only first affected by exposure; extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 6x10-2 µg/m3
E-5 (1 in 100,000) 6x10-3 µg/m3
E-6 (1 in 1,000,000) 6x10-4 µg/m3

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