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Bis(chloroethyl)ether (BCEE) Quickview (CASRN 111-44-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Bis(chloroethyl)ether (BCEE)

File First On-Line: 03/31/1987; Last Significant Revision: 10/01/1991

Category (section)
Status
Last Revised
Oral RfD Assessment No data
Inhalation RfC Assessment Message 10/01/1991
Carcinogenicity Assessment On-line 02/01/1994
Synonyms
  • 111-44-4
  • BCEE
  • beta,beta'-Dichloroethyl ether
  • Bis(chloroethyl)ether
  • Bis(2-chloroethyl) ether
  • Bis(beta-chloroethyl) ether
  • Chlorex
  • 1-Chloro-2-(beta-chloroethoxy)ethane
  • Chloroethyl ether
  • Clorex
  • DCEE
  • more...
Bis(chloroethyl)ether (BCEE) Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Positive carcinogenicity results in two strains of mice and evidence of mutagenicity
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.1 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
3.3x10-5 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 3 µg/L
E-5 (1 in 100,000) 3x10-1 µg/L
E-6 (1 in 1,000,000) 3x10-2 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
3.3 x10-4 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 3x10-1 µg/m3
E-5 (1 in 100,000) 3x10-2 µg/m3
E-6 (1 in 1,000,000) 3x10-3 µg/m3

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