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2,4,6-Trichlorophenol Quickview (CASRN 88-06-2)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 2,4,6-Trichlorophenol

File First On-Line: 01/31/1987; Last Significant Revision: 07/01/1991

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment Message 07/01/1991
Carcinogenicity Assessment Yes 06/01/1990
  • 88-06-2
  • Dowicide 2s
  • NCI-C02904
  • Phenol, 2,4,6-trichloro-
  • RCRA Waste Number U231
  • Trichlorophenol, 2,4,6-
  • Omal
  • Phenachlor
  • 2,4,6-Trichlorophenol
  • Trichlorophenol
2,4,6-Trichlorophenol Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Based on no human data and sufficient evidence in animals; namely, increased incidence of lymphomas or leukemias in male rats and hepatocellular adenomas or carcinomas in male and female mice.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.1 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
3.1x10-7 per µg/L
Risk Level
E-4 (1 in 10,000) 3x102 µg/L
E-5 (1 in 100,000) 3x101 µg/L
E-6 (1 in 1,000,000) 3 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
3.1 x10-6 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
E-4 (1 in 10,000) 3x101 µg/m3
E-5 (1 in 100,000) 3 µg/m3
E-6 (1 in 1,000,000) 3x10-1 µg/m3

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