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1,2,4-Trichlorobenzene Quickview (CASRN 120-82-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for 1,2,4-Trichlorobenzene

File First On-Line: 01/31/1987; Last Significant Revision: 05/01/1992

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 11/01/1996
Inhalation RfC Assessment No data 08/01/1993
Carcinogenicity Assessment On-line 03/01/1991
Synonyms
  • 120-82-1
  • Benzene, 1,2,4-trichloro-
  • 1,2,4-Trichlorobenzene
  • Trichlorobenzene, 1,2,4-
  • Trojchlorobenzen
  • UN 2321
  • Unsym-trichlorobenzene
  • Trichlorobenzene
1,2,4-Trichlorobenzene Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Increased adrenal weights; vacuolization of zona fasciculata in the cortex NOAEL : 1.48 x101 mg/kg-day 1000 1 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
  • Weight-of-Evidence Narrative:
    • A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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