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Thiophanate-methyl Quickview (CASRN 23564-05-8)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Thiophanate-methyl

File First On-Line: 01/31/1987; Last Significant Revision: 01/31/1987

Category (section)
Last Revised
Oral RfD Assessment Yes 01/31/1987
Inhalation RfC Assessment No
Carcinogenicity Assessment No
  • 23564-05-8
  • Allophanic acid, 4,4'-o-phenylenebis(3-thio-, dimethyl ester
  • BAS 32500f
  • 1,2-bis(Methoxycarbonylthioureido)benzene
  • 1,2-bis(3-(Methoxycarbonyl)-2-thioureido)benzene
  • o-bis(3-Methoxycarbonyl-2-thioureido)benzene
  • Carbamic acid, (1,2-phenylenebis(iminocarbonothioyl))bis-, dimethyl ester
  • Cercobin m
  • Cercobin methyl
  • Dimethyl ((1,2-phenylene)bis-(iminocarbonothioyl))bis(carbamate)
  • Dimethyl-4,4'-o-phenylene-bis-(3-thioallophanate)
  • more...
Thiophanate-methyl Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Decreased body weight, decreased spermatogenesis, and histological evidence of hyperthyroidism NOEL : 8 mg/kg-day 100 8 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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