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Tetrachloroethylene Quickview (CASRN 127-18-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Tetrachloroethylene

File First On-Line: 01/31/1987; Last Significant Revision: 02/10/2012

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 02/10/2012
Inhalation RfC Assessment On-line 02/10/2012
Carcinogenicity Assessment On-line 02/10/2012
Synonyms
  • 127-18-4
  • Ankilostin
  • Antisol 1
  • Carbon bichloride
  • Czterochloroetylen
  • Didakene
  • Dowclene ec
  • ENT 1,860
  • Ethylene, tetrachloro-
  • Fedal-UN
  • NCI-C04580
  • more...
Revision History
Date Section Description
02/10/2012 I., II., VI. RfD updated. RfC and cancer assessment added.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Multiple Multiple Multiple 6 x 10-3 mg/kg-day
Neurotoxicity (reaction time, cognitive effects) LOAEL: 9.7 mg/kg-day 1000 candidate RfD = 0.0097 mg/kg-day
Neurotoxicity (color vision) LOAEL: 2.6 mg/kg-day 1,000 candidate RfD = 0.0026 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Multiple Multiple Multiple 4 x 10-2 mg/m3
Neurotoxicity (reaction time, cognitive effects) LOAEL: 56 mg/m3 1,000 candidate RfC = 0.056 mg/m3
Neurotoxicity (color vision) LOAEL: 15 mg/m3 1,000 candidate RfC = 0.015 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Following EPA (2005a) Guidelines for Carcinogen Risk Assessment, tetrachloroethylene is "likely to be carcinogenic in humans by all routes of exposure."
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
2.1 x10-3 per mg/kg-day Multistage model (with linear extrapolation from the point of departure (BMDL10), followed by route-to-route extrapolation to the oral route and interspecies extrapolation using the PBPK model of Chiu and Ginsberg (2011).
Drinking Water Unit Risks
6.1 x10-8 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 2000 µg/L
E-5 (1 in 100,000) 200 µg/L
E-6 (1 in 1,000,000) 20 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
2.6 x10-7 per µg/m3 Multistage model with linear extrapolation from the point of departure (BMCL10), followed by extrapolation to humans using the PBPK model of Chiu and Ginsberg (2011).

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 400 µg/m3
E-5 (1 in 100,000) 40 µg/m3
E-6 (1 in 1,000,000) 4 µg/m3

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