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Sodium cyanide Quickview (CASRN 143-33-9)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Sodium cyanide

File First On-Line: 01/31/1987; Last Significant Revision: 09/28/2010

Category (section)
Last Revised
Oral RfD Assessment Yes 09/28/2010
Inhalation RfC Assessment No
Carcinogenicity Assessment No
  • 143-33-9
  • Hydrocyanic acid, sodium salt
  • Sodium cyanide
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, Supplementary Data were removed from IRIS on or before April, 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Decreased cauda epididymis weight in male F344/N rats. The RfD for potassium cyanide is presented in section I.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. (other effect: Weight loss, thyroid effects and myelin degeneration. ) : x10 1 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

Note: The RfD for Sodium cyanide was calculated using toxicological data for CN-. Please see Toxicological Review of Hydrogen Cyanide and Cyanide Salts (PDF)(154 Pages, 905K, about PDF)

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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