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Pentachlorophenol Quickview (CASRN 87-86-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Pentachlorophenol

File First On-Line: 01/31/1987; Last Significant Revision: 09/30/2010

Category (section)
Last Revised
Oral RfD Assessment Yes 09/30/2010
Inhalation RfC Assessment Discussion 09/30/2010
Carcinogenicity Assessment Yes 09/30/2010
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Pentachlorophenol Source Documents
Revision History
Date Section Description
09/30/2010 I., II., VI. RfD and cancer assessment sections updated. RfC discussion added.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Hepatotoxicity LOAEL : 1.5 mg/kg-day 300 5 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), PCP is "likely to be carcinogenic to humans."
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
4 x10-1 per mg/kg-day Multistage model with linear extrapolation from the POD (LED10).
Drinking Water Unit Risks
1.1x10-5 per µg/L
Risk Level
E-4 (1 in 10,000) 9 µg/L
E-5 (1 in 100,000) 0.9 µg/L
E-6 (1 in 1,000,000) 0.09 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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