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Methyl ethyl ketone (MEK) Quickview (CASRN 78-93-3)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Methyl ethyl ketone (MEK)

File First On-Line: 01/31/1987; Last Significant Revision: 09/26/2003

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/26/2003
Inhalation RfC Assessment On-line 09/26/2003
Carcinogenicity Assessment On-line 09/26/2003
Synonyms
  • 2-Butanone
  • Butanone-2
  • Ethyl methyl cetone
  • Ethylmethylketon
  • Ethyl methyl ketone
  • Ketone, ethyl methyl
  • Meetco
  • Mek
  • Methyl acetone
  • Methyl ethyl ketone
  • Metiletilchetone
  • more...
Methyl ethyl ketone (MEK) Source Documents
Revision History
Date Section Description
I., II., VI. RfD, RfC, and cancer sections updated
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Decreased pup body weight LED05 : 639 mg/kg-day 1000 0.6 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Developmental toxicity (skeletal variations) LEC (HEC): 1517 mg/m3 300 5 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Data are inadequate for an assessment of human carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the draft revised guidelines for carcinogen risk assessment (U.S. EPA, 1999), EPA concludes the data are inadequate for an assessment of human carcinogenic potential of MEK. Studies of humans chronically exposed to MEK are inconclusive, and MEK has not been tested for carcinogenicity in animals by the oral or inhalation routes.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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