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Dichloromethane Quickview (CASRN 75-09-2)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Dichloromethane

File First On-Line: 01/31/1987; Last Significant Revision: 11/18/2011

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 11/18/2011
Inhalation RfC Assessment On-line 11/18/2011
Carcinogenicity Assessment On-line 11/18/2011
Synonyms
  • 75-09-2
  • Chlorure de methylene
  • DCM
  • Dichlormethan, uvasol
  • Dichloromethane
  • 1,1-Dichloromethane
  • Freon 30
  • Methane dichloride
  • Methane, dichloro-
  • Methylene bichloride
  • Methylene chloride
  • more...
Dichloromethane Source Documents
Revision History
Date Section Description
11/18/2011 I., II, VI. RfD and cancer assessment updated. RfC added.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Hepatic effects (hepatic vacuolation, liver foci) BMDL10 (HED): 0.19 mg/kg-day 30 6 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Hepatic effects (hepatic vacuolation) BMDL10 (HEC): 17.2 mg/m3 30 6x10-1 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Following U.S. EPA (2005a) Guidelines for Carcinogen Risk Assessment, dichloromethane is "likely to be carcinogenic in humans," based predominantly on evidence of carcinogenicity at two sites in 2-year bioassays in male and female B6C3F1 mice (liver and lung tumors) with inhalation exposure (NTP, 1986) and at one site in male B6C3F1 mice (liver tumors) with drinking water exposure (Serota et al., 1986b Hazleton Laboratories, 1983).
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
2 x10-3 per mg/kg-day Multistage model with linear extrapolation from the point of departure (BMDL10).
  • EPA has concluded, by a weight of evidence evaluation, that Dichloromethane is carcinogenic by a mutagenic mode of action. As a result, increased early-life susceptibility is assumed and the age-dependent adjustment factors (ADAFs) should be used when estimating age-specific cancer risks. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
1 x10-8 per µg/m3 Multistage model with linear extrapolation from the point of departure (BMDL10).
  • EPA has concluded, by a weight of evidence evaluation, that Dichloromethane is carcinogenic by a mutagenic mode of action. As a result, increased early-life susceptibility is assumed and the age-dependent adjustment factors (ADAFs) should be used when estimating age-specific cancer risks. See IRIS Summary.

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