Jump to main content.


Isophorone Quickview (CASRN 78-59-1)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Isophorone

File First On-Line: 01/31/1987; Last Significant Revision: 10/01/1992

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 01/01/1991
Inhalation RfC Assessment Message 03/01/1991
Carcinogenicity Assessment On-line 11/01/1992
Synonyms
  • 78-59-1
  • Isoacetophorone
  • Isoforon
  • Isophoron
  • alpha-Isophoron
  • Isophorone
  • alpha-Isophorone
  • 3,5,5-Trimethyl-2-cyclohexenone
Isophorone Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
No observed effects (other effect: Kidney pathology. ) NOEL : 1.50 x102 mg/kg-day 1000 2 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

Top of page


Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

Top of page

Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • C (Possible human carcinogen)
  • Weight-of-Evidence Narrative:
    • Based on no data in humans; limited evidence of carcinogenicity of one tumor type in one sex of one animal species as shown by an increase of preputial gland carcinomas in male rats. The apparent renal tubular cell tumor in the male rat is associated with alpha-2u-globulin, considered to be of questionable relevance to humans.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
9.5 x10-4 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
2.7x10-8 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 4x103 µg/L
E-5 (1 in 100,000) 4x102 µg/L
E-6 (1 in 1,000,000) 4x101 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

Top of page


Recent Additions | Advanced Search | IRIS Home | Environmental Assessment | Research


Local Navigation


Jump to main content.