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Epichlorohydrin Quickview (CASRN 106-89-8)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Epichlorohydrin

File First On-Line: 01/31/1987; Last Significant Revision: 04/01/1992

Category (section)
Status
Last Revised
Oral RfD Assessment Withdrawn 04/01/1992
Inhalation RfC Assessment On-line 04/01/1992
Carcinogenicity Assessment On-line 02/01/1994
Synonyms
  • 1-Chlor-2,3-epoxypropane
  • y-Chloropropyleneoxide
  • Epichlorhydrin
  • 106-89-8
  • Chloromethyloxirane
  • 2-Chloropropylene oxide
  • Epichlorohydrin
Epichlorohydrin Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advirsories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Information reviewed but value not estimated. See IRIS Summary.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Changes in the nasal turbinates NOAEL (HEC): 3.6 x10-1 mg/m3 300 1x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Human data are inadequate. Multiple studies in rats and mice administered epichlorohydrin by various routes were positive. As epichlorohydrin is a strong alkylating agent, tumors are produced at the site of application.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
9.9 x10-3 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
2.8x10-7 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 3x102 µg/L
E-5 (1 in 100,000) 3x101 µg/L
E-6 (1 in 1,000,000) 3 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
1.2 x10-6 per µg/m3 Linearized multistage procedure, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 8x101 µg/m3
E-5 (1 in 100,000) 8 µg/m3
E-6 (1 in 1,000,000) 8x10-1 µg/m3

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