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N-Nitrosodiethylamine Quickview (CASRN 55-18-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for N-Nitrosodiethylamine

File First On-Line: 01/31/1987; Last Significant Revision: 01/31/1987

Category (section)
Last Revised
Oral RfD Assessment No
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 01/31/1987
  • 55-18-5
  • Dana: den
  • Dena
  • Diaethylnitrosamin
  • Diethylamine, n-nitroso
  • Diethylnitrosamine
  • Diethylnitrosoamine
  • Ethylamine, n-nitrosodi-
  • Ndea
  • n-Ethyl-n-nitroso-ethanamine
  • Nitrosodiethylamine
  • more...
N-Nitrosodiethylamine Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Not Assessed under the IRIS Program.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Induction of tumors at multiple sites in both rodent and nonrodent species exposed by various routes.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.5 x102 per mg/kg-day Weibull, extra risk
Drinking Water Unit Risks
4.3x10-3 per µg/L
Risk Level
E-4 (1 in 10,000) 2x10-2 µg/L
E-5 (1 in 100,000) 2x10-3 µg/L
E-6 (1 in 1,000,000) 2x10-4 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
4.3 x10-2 per µg/m3 Weibull, extra risk

Inhalation Concentrations at Specified Risk Levels

Risk Level
E-4 (1 in 10,000) 2x10-3 µg/m3
E-5 (1 in 100,000) 2x10-4 µg/m3
E-6 (1 in 1,000,000) 2x10-5 µg/m3

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