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2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) Quickview (CASRN 1163-19-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209)

File First On-Line: 01/31/1987; Last Significant Revision: 06/30/2008

Category (section)
Last Revised
Oral RfD Assessment Yes 06/30/2008
Inhalation RfC Assessment Discussion 06/30/2008
Carcinogenicity Assessment Yes 06/30/2008
  • 1163-19-5
  • Decabromobiphenyl ether
  • Decabromobiphenyl oxide
  • Decabromodiphenyl ether
  • Decabromodiphenyl oxide
  • Decabromophenyl ether
  • Ether, bis(pentabromophenyl)
  • Ether, decabromodiphenyl
  • Benzene, 1,1'-oxybis(2,3,4,5,6-pentabromo-
  • more...
Revision History
Date Section Description
06/30/2008 I., II., VI. RfD, RfC, and cancer assessment sections updated.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Neurobehavioral effects NOAEL : 2.22 mg/kg 300 7 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Suggestive evidence of carcinogenic potential
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for decabromodiphenyl ether provides suggestive evidence of carcinogenic potential.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
7 x10-4 per mg/kg-day Multistage model with linear extrapolation from the point of departure (LED12).
Drinking Water Unit Risks
2x10-8 per µg/L
Risk Level
E-4 (1 in 10,000) 5000 µg/L
E-5 (1 in 100,000) 500 µg/L
E-6 (1 in 1,000,000) 50 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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