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Cyanogen Quickview (CASRN 460-19-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Cyanogen

File First On-Line: 01/31/1987; Last Significant Revision: 09/28/2010

Category (section)
Last Revised
Oral RfD Assessment Yes 09/28/2010
Inhalation RfC Assessment No
Carcinogenicity Assessment No
  • 460-19-5
  • Cyanogene
  • Dicyan
  • Nitriloacetonitrile
  • Oxalic nitrile
  • Oxalyl cyanide
  • Prussite
  • Carbon nitride
  • Oxalic acid dinitrile
  • RCRA Waste Number p031
  • Cyanogen
  • UN 1026
Revision History
Date Section Description
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Decreased cauda epididymis weight in male F344/N rats. The RfD for cyanogen is presented in section I.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. (other effect: Weight loss, thyroid effects and myelin degeneration. ) : x10 1 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

Note: The RfD for Cyanogen was calculated using toxicological data for CN-. Please see Toxicological Review of Hydrogen Cyanide and Cyanide Salts (PDF)(154 Pages, 905K, about PDF)

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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