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Cyanide, free Quickview (CASRN 57-12-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Cyanide, free

File First On-Line: 01/31/1987; Last Significant Revision: 09/28/2010

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 09/28/2010
Inhalation RfC Assessment No data
Carcinogenicity Assessment On-line 03/01/1991
Synonyms
  • Carbon nitride ion
  • Cyanide anion
  • Cyanide
  • Cyanide, free
  • 57-12-5
  • Cyanide ion
  • Cyanure
  • Free cyanide
  • RCRA Waste Number p030
  • Isocyanide
Revision History
Date Section Description
09/28/2010 I.A. Updated RfD with data from Hydrogen Cyanide and Cyanide Salts Assessment
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
: x10 6 x10-4 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.


Note: The RfD for Cyanide, free was calculated using toxicological data for CN-. Please see Toxicological Review of Hydrogen Cyanide and Cyanide Salts (PDF)(154 Pages, 905K, about PDF)

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
  • Weight-of-Evidence Narrative:
    • Pertinent data regarding carcinogenicity have not been located in the available literature.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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