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Carbon tetrachloride Quickview (CASRN 56-23-5)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

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Status of Data for Carbon tetrachloride

File First On-Line: 01/31/1987; Last Significant Revision: 03/31/2010

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 03/31/2010
Inhalation RfC Assessment On-line 03/31/2010
Carcinogenicity Assessment On-line 03/31/2010
Synonyms
  • 56-23-5
  • Acritet
  • Benzinoform
  • Carbona
  • Carbon chloride
  • Carbon tet
  • Carbon tetrachloride
  • Carbo tetrachloride
  • Czterochlorek wegla
  • ENT 4,705
  • Fasciolin
  • more...
Carbon tetrachloride Source Documents
Revision History
Date Section Description
03/31/2010 I., II., VI. RfD and cancer assessment sections updated RfC assessment added.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Elevated serum SDH activity BMD2x (ADJ): 3.9 mg/kg-day 1000 0.004 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Fatty changes in the liver BMCL10 (HEC): 14.3 mg/m3 100 0.1 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • Likely to be carcinogenic to humans
  • Weight-of-Evidence Narrative:
    • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), carbon tetrachloride is "likely to be carcinogenic to humans."
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
7 x10-2 per mg/kg-day Multistage model with linear extrapolation from the POD (LED10).
Drinking Water Unit Risks
2x10-6 per µg/L
Risk Level
Concentration
E-4 (1 in 10,000) 50 µg/L
E-5 (1 in 100,000) 5 µg/L
E-6 (1 in 1,000,000) 0.5 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

Inhalation Unit Risk(s)
Extrapolation Method
6 x10-6 per µg/m3 Log-probit model with linear extrapolation from the POD (LEC10).

Inhalation Concentrations at Specified Risk Levels

Risk Level
Concentration
E-4 (1 in 10,000) 17 µg/m3
E-5 (1 in 100,000) 1.7 µg/m3
E-6 (1 in 1,000,000) 0.17 µg/m3

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